Illumina

Associate Principal, AI Engineer

Illumina San Diego, CA, US
Full-time $187k - $281k Posted 2 months ago

Role overview

  • check_circle Set the technical direction for AI Engineering across foundation model integration, fine-tuning pipelines, RAG systems, agentic workflows, and evaluation infrastructure.
  • check_circle Own the most complex and ambiguous AI engineering problems in the company, from initial design through production deployment and ongoing optimization.
  • check_circle Establish engineering standards for model development, prompt management, evaluation, deployment, and observability that the rest of the AI organization adopts.
  • check_circle Lead architecture reviews and serve as the senior technical reviewer for high-stakes AI initiatives.
  • check_circle Design and build production-grade Generative AI systems including retrieval-augmented generation, multi-agent orchestration, tool-using agents, and domain-adapted models.
  • check_circle Develop fine-tuning, distillation, and post-training pipelines using techniques such as SFT, DPO, RLHF, and parameter-efficient methods (LoRA, QLoRA, adapters).
  • check_circle Architect and implement vector retrieval systems, semantic search, and hybrid retrieval pipelines optimized for accuracy, latency, and cost.
  • check_circle Build robust evaluation frameworks covering automated metrics, LLM-as-judge, human review, regression testing, and safety evaluations.
  • check_circle Design and build the AI platform that powers internal teams, including model serving infrastructure, prompt and prompt-template management, experiment tracking, and feature stores.
  • check_circle Optimize inference performance across latency, throughput, and cost, including quantization, batching, caching, speculative decoding, and intelligent routing across model providers.
  • check_circle Establish LLMOps practices for continuous evaluation, drift detection, prompt versioning, rollback strategies, and incident response.
  • check_circle Partner with platform and infrastructure teams to ensure AI workloads run reliably on GPU and accelerator hardware across cloud environments.
  • check_circle Stay current with the rapidly evolving AI research landscape and identify which advances translate into production value for the business.
  • check_circle Prototype emerging techniques (new model architectures, training methods, agent frameworks) and lead the path from experiment to production system.
  • check_circle Contribute to internal technical strategy on build versus buy decisions for foundation models, vector databases, agent frameworks, and AI tooling.
  • check_circle Partner with product, data science, research, and business stakeholders to scope AI initiatives and shape solutions that deliver measurable business impact.
  • check_circle Mentor senior and staff engineers, raising the technical bar across the AI organization.
  • check_circle Represent AI Engineering in executive forums, customer conversations, vendor evaluations, and industry engagements.
  • check_circle Author technical documents, design docs, and (where appropriate) external publications that contribute to the broader AI community.

Basic qualifications

  • 12+ years of software engineering experience, with 6+ years focused on machine learning or AI systems and 2+ years building production Generative AI applications.
  • Demonstrated ownership of large-scale AI systems in production, including responsibility for latency, cost, accuracy, and reliability outcomes.
  • Deep hands-on expertise in Python and modern ML frameworks (PyTorch, TensorFlow, JAX, Hugging Face Transformers).
  • Strong command of LLM application development, including RAG architectures, prompt engineering, function calling, structured outputs, and agentic patterns.
  • Experience with model fine-tuning, evaluation, and deployment lifecycles across at least one major cloud platform (GCP, Azure, or AWS).
  • Proven ability to design distributed systems, including familiarity with vector databases, message queues, container orchestration, and observability stacks.
  • Bachelor's or Master's degree in Computer Science, Machine Learning, Statistics, or a related quantitative discipline. PhD welcomed but not required.

Preferred qualifications

  • Experience training, fine-tuning, or post-training foundation models using techniques such as SFT, DPO, RLHF, RLAIF, or constitutional methods.
  • Familiarity with agentic frameworks (LangChain, LangGraph, AutoGen, CrewAI, custom orchestration) and multi-agent system design patterns.
  • Background in Voice AI, speech systems, multimodal models, or computer vision applied at production scale.
  • Contributions to open source AI projects, peer-reviewed publications, or notable conference presentations.
  • Experience in regulated or high-stakes domains (life sciences, healthcare, financial services) where accuracy, safety, and governance requirements are stringent.
  • Familiarity with responsible AI practices including red-teaming, jailbreak resistance, content safety, bias evaluation, and AI governance frameworks.
  • Typically requires a minimum of 15 years of related experience with a Bachelor’s degree; or 12 years and a Master’s degree; or a PhD with 8 years experience; or equivalent experience.
  • Technical Depth: Expert-level mastery of AI engineering with the ability to operate from research papers down to production code.
  • Systems Thinking: Comfort designing systems that span multiple services, data stores, model providers, and failure modes.
  • Pragmatism: Strong instinct for when to build, when to buy, and when to wait, with a track record of avoiding over-engineering.
  • Communication: Ability to explain complex AI concepts to executives, write design docs that drive decisions, and influence peers across disciplines.
  • Builder's Mindset: Genuine enjoyment of writing code and solving hard technical problems, not just reviewing or directing others.
  • Curiosity and Continuous Learning: Active engagement with the AI research landscape and a habit of trying new things.

Tags & Focus Areas

Fulltime Ai Ai Engineer

About Illumina